Fig. 3: PTSD-TBI-common miRNAs reported in TBI.
From: Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury
The eight PTSD-TBI-common miRNAs also play important roles in TBI. Overexpression of miR-153-3p, miR-142-5p, miR-144, and miR-let-7a-5p is reported in the pathological processes of TBI; inhibition of miR-598-3p, miR-138-5p shows neuroprotection effects. Moreover, inhibition of miR-132 is detrimental, and persistent downregulation of miR-124-3p can lead to neurodegeneration and inflammation, while evidence also suggests that inhibition of miR-124-3p promotes stem cell activation and motor function recovery.
