Table 2 Summary of miRNAs reported in recent PTSD clinical studies.
From: Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury
Study | miRNA | Sample | PTSD model | Location | Findings in PTSD | Reported in TBI |
|---|---|---|---|---|---|---|
2020 Bam et al. | miR-7113-5p | human | Not applicable | PBMCs | miR-7113-5p is decreased in PTSD patients and downregulated miR-7113-5p promotes inflammation by targeting the WNT signaling pathway | No |
2022 Busbee et al. | miR-let-7a-5p | human | / | PBMCs | Downregulated miR-let-7a-5p promotes an inflammatory TH17 phenotype | Yes 2019 A.M. Svingos et al. |
2020 S.D. Linnstaedt et al. | miR-19b | human, rat | Not applicable; SPS and USS | human: blood; rat: amygdala, hippocampus, hypothalamus, adrenal glands, dorsal root ganglion, peripheral nerve, and blood | miR-19b might play a role in the development of PTWP and PTSS after exposure | No |
