Fig. 2: Synapse-related transcriptomic changes in the Adnp-HT juvenile and adult hippocampus as revealed by DEG analyses. | Molecular Psychiatry

Fig. 2: Synapse-related transcriptomic changes in the Adnp-HT juvenile and adult hippocampus as revealed by DEG analyses.

From: Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits

Fig. 2: Synapse-related transcriptomic changes in the Adnp-HT juvenile and adult hippocampus as revealed by DEG analyses.

a Volcano plots of DEGs (adjusted p < 0.05; light red/blue) in adult and juvenile Adnp-HT transcripts. Stroger DEGs with significant changes in p values and fold changes (FCs; threshold >1.5) are indicated in darker red/blue colors. b Numbers of up/downregulated DEGs in adult and juvenile Adnp-HT transcripts shown in the tables and Venn diagrams. c DAVID analyses of DEGs in adult and juvenile Adnp-HT transcripts, in domains of KEGG (Kyoto encyclopedia of genes and genomes), cellular component, biological process, and molecular function. d Venn diagrams showing the overlap between juvenile and adult Adnp-HT DEGs and SynGO genes. e SynGO analyses of DEGs in juvenile and adult Adnp-HT transcripts. Note that significant enrichment is observed only in upregulated adult DEGs, where postsynaptic enrichment is stronger than presynaptic enrichment.

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