Fig. 3: Synapse- and ASD-related transcriptomic changes in the Adnp-HT juvenile and adult hippocampus, as revealed by GSEA.

GSEA results for juvenile (a) and adult (b) Adnp-HT transcripts using the gene sets in the cellular component (CC), biological process (BP), and molecular function (MF) domains of the C5 database (https://www.gsea-msigdb.org), as shown by enriched gene set clustering performed using Cytoscape EnrichmentMap App (https://cytoscape.org). The size of each node/circle indicates the number of genes in the gene set. The blue and red colors of the nodes indicate negative and positive enrichments, respectively. As the transcriptomic changes are stronger in adults than in juveniles, we show all the positive clusters for juveniles but only those with more than four gene sets for adults. c GSEA results for juvenile and adult Adnp-HT transcripts using ASD-related gene sets (DEG Up, Co-Exp Up M16, DEG Down, and Co-Exp Down M12), ASD-risk gene sets (SFARI, FMRP target, De Novo Missense, De Novo Variants, and AutismKB).