Table 5 Fetal CBD exposure impairs problem-solving in female, but not male offspring.

From: Fetal cannabidiol (CBD) exposure alters thermal pain sensitivity, problem-solving, and prefrontal cortex excitability

Puzzle Box Test

Measure

Female vehicle

Female CBD

Female effect size

N pups

N litters

Mean latency (sec) ± SEM

N pups

N litters

Mean latency (sec) ± SEM

Vehicle - CBD Mean

Opendoor

Trial 1

12

5

23.08 ± 9.20

12

4

17.00 ± 5.90

6.08

Underpass

Trial 2

12

5

11.42 ± 3.05

12

4

13.83 ± 2.41

−2.41

Underpass

Trial 3

12

5

7.58 ± 1.22

12

4

20.08 ± 12.29

−12.5

Underpass

Trial 4

12

5

5.18 ± 0.89

12

4

7.00 ± 1.45

−1.82

Clogged underpass

Trial 5

12

5

68.58 ± 24.31

12

4

95.75 ± 17.47

−27.17

Clogged underpass

Trial 6

12

5

26.00 ± 6.75

12

4

38.92 ± 9.95

−12.92

Clogged underpass

Trial 7

12

5

18.00 ± 2.67

12

4

23.50 ± 6.03

−5.5

Covered clogged underpass

Trial 8

12

5

132.50 ± 25.88

12

4

133.58 ± 35.93

97.65

Covered clogged underpass

Trial 9

12

5

71.75 ± 20.81

12

4

139.42 ± 26.91

−68.16

Puzzle Box Test

Measure

Male vehicle

Male CBD

Male effect size

N pups

N litters

Mean latency (sec) ± SEM

N pups

N litters

Mean latency (sec) ± SEM

Vehicle - CBD mean

Opendoor

Trial 1

12

4

61.67 ± 16.88

12

4

42.58 ± 9.53

19.14

Underpass

Trial 2

12

4

19.67 ± 5.85

12

4

16.50 ± 2.75

3.17

Underpass

Trial 3

12

4

9.82 ± 2.85

12

4

9.18 ± 1.63

0.64

Underpass

Trial 4

12

4

8.75 ± 1.37

12

4

9.25 ± 0.84

−0.5

Clogged underpass

Trial 5

12

4

134.92 ± 24.15

12

4

130.58 ± 26.44

4.34

Clogged underpass

Trial 6

12

4

54.33 ± 15.73

12

4

54.67 ± 18.58

−0.34

Clogged underpass

Trial 7

12

4

57.75 ± 17.49

12

4

57.67 ± 15.95

0.08

Covered clogged underpass

Trial 8

12

4

147.42 ± 17.61

12

4

109.08 ± 25.59

38.34

Covered clogged underpass

Trial 9

12

4

99.25 ± 17.41

12

4

102.67 ± 21.86

−3.42

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