Fig. 1: LHb neurons can show excitatory or inhibitory responses to foot shock.
From: Plasticity of neuronal dynamics in the lateral habenula for cue-punishment associative learning
a Experimental protocol related to the extracellular single-unit electrophysiological recordings in anesthetized mice; for each recorded neuron, mice received between 20 and 120 contralateral foot shocks. b Electrophysiological trace, raster plot, average firing response, and picture of an example foot shock-excited neuron labeled in the LHb (scale bar top=500 µm, bottom=100 µm). c Same as b but for a foot shock-inhibited neuron. d Heatmap of single neuron z-scored average response to FS presentation (nneurons=196; nneurons EXC = 134, nneurons INH = 37, nneurons NR = 25). e t-SNE plots with superimposed color-coded FS-modulation index (top) and baseline firing rate (bottom). f scatter plot with linear correlation of firing rate and modulation index with all cells (nneurons = 196, ***p < 0.001).
