Table 2 Novel genomic loci associated with latent class membership.
From: Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse
Class | Locus | CHR | Start BP | End BP | Lead SNP | P | Nearest Gene | GWAS Catalog Associations |
|---|---|---|---|---|---|---|---|---|
Broad-Low | 16 | 21 | 40516308 | 40741846 | 21:40710198:T_TA | 2.93E-13 | HMGN1 | Age of menarche, BMI, platelets |
Heavy-Int | 1 | 1 | 933790 | 1019180 | 1:962891:C_T | 1.91E-09 | AGRN | Blood protein levels |
Heavy-Int | 2 | 1 | 50839740 | 51506413 | 1:50984962:C_T | 2.50E-10 | FAF1 | Baldness, carcinoma, cholesterol, headache, hippocampal tail volume, lung function, math ability, type 2 diabetes |
Heavy-Int | 15 | 9 | 20662649 | 20694595 | 9:20662649:G_T | 1.22E-09 | FOCAD | - |
Heavy-Int | 22 | 18 | 21075441 | 21165409 | 18:21156719:C_T | 7.27E-11 | NPC1 | BMI, cholesterol, cognitive ability, educational attainment |
Heavy-Int | 25 | 20 | 35493755 | 35737816 | 20:35567830:G_T | 4.94E-10 | SAMHD1 | Airway wall thickness |
Heavy-Int / Broad-Int | 8/10 | 3 | 71492037 | 71611630 | 3:71557945:A_C | 2.84E-09 | FOXP1 | Autism, cancer, cognitive ability, educational attainment, lung function, nasal polyps, vitiligo |
Broad-Int | 2 | 1 | 93514059 | 93519168 | 1:93519168:T_TA | 1.19E-09 | MTF2 | - |
Broad-Int | 8 | 3 | 48731450 | 50209053 | 3:49250007:C_T | 8.38E-13 | IHO1 | Age at first birth, age at menarche blood pressure, BMI, bone density, cognitive ability, educational attainment, protein levels, sunburns |
Broad-Int | 19 | 5 | 145451731 | 145705669 | 5:145660413:T_TTTTA | 2.95E-09 | RBM27 | Educational attainment, math ability |
Broad-Int | 24 | 7 | 141668403 | 141673345 | 7:141673345:C_G | 3.67E-09 | MGAM, TAS2R38 | Bitter taste perception |
Broad-Int | 28 | 8 | 143475927 | 143534117 | 8:143534117:C_T | 1.10E-09 | BAI1 | Math ability |
Broad-Int | 32 | 12 | 71298675 | 71394179 | 12:71363764:C_T | 3.52E-08 | CTD-2021H9.1 | - |
Broad-Int | 50 | X | 55360035 | 56653185 | X:56274351:A_G | 4.79E-10 | KLF8 | Antigen levels, corpuscular volume |
