Fig. 4: Reduced functional connectivity within hippocampus (dentate gyrus) of NR1 mice compared to controls (cohort 1). | Molecular Psychiatry

Fig. 4: Reduced functional connectivity within hippocampus (dentate gyrus) of NR1 mice compared to controls (cohort 1).

From: Impaired functional connectivity of the hippocampus in translational murine models of NMDA-receptor antibody associated neuropsychiatric pathology

Fig. 4: Reduced functional connectivity within hippocampus (dentate gyrus) of NR1 mice compared to controls (cohort 1).

A Dual regression analysis revealed reduced functional connectivity of adult NR1 mice compared to controls (significantly different area displayed based on p-values in blue-lightblue) in a specific functional component (component area displayed as z-map in red-yellow). B Functional component and corresponding area of functional connectivity reduction is affiliated with frontal (but not posterior) parts of the left-hemispheric hippocampus (light-green region of interest) and C shows visual correspondence with the frontal parts of the hippocampal subfield dentate gyrus (green). No significant differences were seen at the middle or posterior portions of the dentate gyrus / hippocampal formation. DG = dentate gyrus.

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