Fig. 5: Reduced functional connectivity within hippocampus of NR1 offspring at different stages of age compared to controls (cohort 2 and 3). | Molecular Psychiatry

Fig. 5: Reduced functional connectivity within hippocampus of NR1 offspring at different stages of age compared to controls (cohort 2 and 3).

From: Impaired functional connectivity of the hippocampus in translational murine models of NMDA-receptor antibody associated neuropsychiatric pathology

Fig. 5: Reduced functional connectivity within hippocampus of NR1 offspring at different stages of age compared to controls (cohort 2 and 3).

A Dual regression analysis revealed reduced functional connectivity of 8-week-old NR1 offspring with neurodevelopmental disorder compared to controls (significantly different area displayed based on p-values in blue-lightblue) in a specific functional component (component area displayed as z-map in red-yellow) affiliated with left-hemispheric hippocampus (light-green region of interest) and B shows visual correspondence with hippocampal subfield with frontal (but not posterior) parts of dentate gyrus (green). C Reduced functional connectivity of 10-month-old NR1 offspring is detectable in a functional component corresponding with left-hemispheric hippocampus (light-green region of interest). D Visual correspondence of impaired connectivity cluster with hippocampal subfield of dentate gyrus (green) and CA3 (white). DG = dentate gyrus.

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