Fig. 5: Mice injected with the D2R agonist Sumanirole: predicted social behavior and locomotor activity based on modeled data. | Molecular Psychiatry

Fig. 5: Mice injected with the D2R agonist Sumanirole: predicted social behavior and locomotor activity based on modeled data.

From: The human neuropsychiatric risk gene Drd2 is necessary for social functioning across evolutionary distant species

Fig. 5

Data is presented as the increase in time spent approaching conspecifics compared to baseline (A), the increase in time spent sniffing conspecifics compared to baseline (B) and the increase in total distance moved compared to baseline (C) on the Y-axis (mean ± SEM) based on 1-hour bins, with time from injection on the X-axis in hours. Sumanirole-treated animals (n = 9) are shown as the red lines, vehicle-treated animals (n = 9 s) are shown as blue lines. Yellow shading behind the graph indicates the light phase, whereas gray shading indicates the dark phase. *p < 0,05 based on difference plots after modeling the data with a GAM. (see figures S11-S13 for individual data points and means of observed values).

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