Fig. 4: Effect of the BK α K361N substitution on acute alcohol sensitivity in vivo. | Molecular Psychiatry

Fig. 4: Effect of the BK α K361N substitution on acute alcohol sensitivity in vivo.

From: Ethanol’s interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice

Fig. 4: Effect of the BK α K361N substitution on acute alcohol sensitivity in vivo.The alternative text for this image may have been generated using AI.

Measures of alcohol metabolism and intoxication were obtained in BK α K361N WT, Het and KI males acutely exposed to ethanol (i.p.). A. Blood ethanol concentration (BEC) clearance time-course.Ethanol-induced ataxia (B, fixed-speed rotarod), sedation (C, loss of righting response), hypothermia (D), analgesia (E, tail pressure test) and reward (F, conditioned place preference). Main effect of ethanol: ###p < 0.001. None of the measures was significantly affected by genotype.

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