Fig. 3: Whole-brain voxel-wise regression of brain volumes and rate of volume change on inflammatory components. | Molecular Psychiatry

Fig. 3: Whole-brain voxel-wise regression of brain volumes and rate of volume change on inflammatory components.

From: Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition

Fig. 3: Whole-brain voxel-wise regression of brain volumes and rate of volume change on inflammatory components.

A Higher levels of inflammatory component PC1 were related to higher GM volume (orange) at baseline in bilateral hippocampus, left amygdala and putamen and higher WM volume (green) in temporal regions and brain stem. N = 258. B Higher levels of the inflammatory component PC2 were related to lower GM volume (light blue) at baseline in bilateral hippocampus, right thalamus and right putamen and lower WM volume (dark blue) in frontal and other regions. N = 258. C Levels of the PC1 were positively related to rate of change in GM volume (i.e., less/slower atrophy over follow-ups) in anterior medial temporal lobe, posterior inferior temporal cortex and posterior cingulate cortex (orange). N = 174. Results are depicted at p < 0.05 (FWE, cluster-level, cluster forming voxel-level threshold p = 0.001). See Supplementary Fig. 3 for results at voxel-level threshold p = 0.005. All analyses were accounting for age, gender, ICV, p-tau181, Aβ42/40. L Left, R Right, A Anterior, P Posterior.

Back to article page