Fig. 1: Bayesian posterior distribution plots of the differences in white matter microstructure between (a) OCD patients and healthy controls and (b) early and late onset OCD patients.
From: Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
The posterior distribution communicates the credibility of an effect. Posterior probabilities of a positive effect (P + ) are shown next to each distribution and color coded. P+ values ≥ 0.90 (moderate to very high credibility for a positive effect) or ≤0.10 (moderate to very high credibility for a negative effect) are presented in bold. The meaning of the direction of effects are shown next to the red zero-effect line. Values on the X-axis represent (inverted) Z-scores (i.e., the unit to which the tensor/NODDI measures were converted; see methods section). A There was no credible evidence for differences between OCD patients and healthy controls (all 0.10 < P + < 0.90). B P+ values were ≤ 0.10 for several tensor/NODDI measures of the posterior thalamic radiation and superior longitudinal fascicle, signifying moderate to high credibility for a higher value in early onset OCD patients. abbreviations: AD: axial diffusivity, FA: fractional anisotropy, MD mean diffusivity, ND neurite density, OD orientation dispersion, RD radial diffusivity, NODDI Neurite orientation dispersion and density imaging. Plots were produced using the Region-Based Analysis program through Bayesian Multilevel Modeling implemented in AFNI (Chen et al. 2019).
