Table 2 Case-Control mixed model analyses of white matter microstructure – ComBat corrected.

From: Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure

 

HC

OCD

Group difference (crude model)

Group difference (adjusted model)*

M ± SD

M ± SD

B [SE]

95% CI

P (unc)

B [SE]

95% CI

P (unc)

CC genu

 Overall diffusion

  

0.046 [0.050]

−0.06 | 0.15

0.905 (0.389)

0.023 [0.050]

−0.08 | 0.12

0.940 (0.652)

     AD

1.522 ± 0.052

1.523 ± 0.050

0.004 [0.090]

−0.17 | 0.18

0.963 (0.963)

−0.019 [0.090]

−0.19 | 0.15

0.831 (0.831)

     FA

0.749 ± 0.036

0.753 ± 0.034

0.096 [0.090]

−0.08 | 0.27

0.664 (0.279)

0.073 [0.090]

−0.10 | 0.24

0.753 (0.403)

     MD

0.732 ± 0.035

0.730 ± 0.036

0.052 [0.090]

−0.12 | 0.22

0.638 (0.559)

0.029 [0.090]

−0.14 | 0.20

0.833 (0.740)

     RD

0.339 ± 0.046

0.336 ± 0.044

0.073 [0.090]

−0.10 | 0.25

0.608 (0.410)

0.050 [0.090]

−0.12 | 0.22

0.726 (0.565)

     ND

0.646 ± 0.040

0.649 ± 0.038

0.082 [0.090]

−0.09 | 0.26

0.898 (0.355)

0.059 [0.090]

−0.11 | 0.23

0.906 (0.499)

     OD

0.086 ± 0.009

0.086 ± 0.010

−0.032 [0.090]

−0.20 | 0.14

0.833 (0.720)

−0.054 [0.090]

−0.22 | 0.12

0.879 (0.533)

CC body

 Overall diffusion

  

0.083 [0.050]

−0.02 | 0.19

0.905 (0.127)

0.068 [0.050]

−0.04 | 0.17

0.940 (0.211)

     AD

1.508 ± 0.046

1.512 ± 0.046

0.086 [0.090]

−0.09 | 0.26

0.454 (0.333)

0.070 [0.090]

−0.10 | 0.24

0.570 (0.426)

     FA

0.735 ± 0.042

0.742 ± 0.037

0.172 [0.090]

0.00 | 0.34

0.468 (0.052)

0.156 [0.090]

−0.02 | 0.33

0.693 (0.077)

     MD

0.727 ± 0.035

0.725 ± 0.033

0.051 [0.090]

−0.12 | 0.22

0.638 (0.567)

0.035 [0.090]

−0.14 | 0.21

0.833 (0.688)

     RD

0.353 ± 0.051

0.347 ± 0.047

0.135 [0.090]

−0.04 | 0.31

0.603 (0.126)

0.120 [0.090]

−0.05 | 0.29

0.690 (0.174)

     ND

0.655 ± 0.034

0.656 ± 0.033

0.026 [0.090]

−0.15 | 0.20

0.898 (0.772)

0.010 [0.090]

−0.16 | 0.18

0.906 (0.906)

     OD

0.083 ± 0.009

0.083 ± 0.009

0.030 [0.090]

−0.14 | 0.20

0.833 (0.735)

0.015 [0.090]

−0.16 | 0.19

0.879 (0.867)

CC splenium

 Overall diffusion

  

0.029 [0.060]

−0.08 | 0.14

0.944 (0.604)

0.016 [0.060]

−0.09 | 0.12

0.940 (0.780)

     AD

1.586 ± 0.051

1.591 ± 0.051

0.091 [0.090]

−0.08 | 0.26

0.454 (0.303)

0.077 [0.090]

−0.10 | 0.25

0.570 (0.380)

     FA

0.834 ± 0.024

0.835 ± 0.021

0.073 [0.090]

−0.10 | 0.25

0.664 (0.411)

0.059 [0.090]

−0.11 | 0.23

0.753 (0.502)

     MD

0.699 ± 0.023

0.699 ± 0.026

−0.001 [0.090]

−0.17 | 0.17

0.990 (0.990)

−0.015 [0.090]

−0.19 | 0.16

0.868 (0.868)

     RD

0.243 ± 0.030

0.242 ± 0.027

0.049 [0.090]

−0.12 | 0.22

0.650 (0.578)

0.036 [0.090]

−0.14 | 0.21

0.773 (0.687)

     ND

0.724 ± 0.031

0.724 ± 0.03

−0.011 [0.090]

−0.18 | 0.16

0.898 (0.898)

−0.025 [0.090]

−0.2 | 0.15

0.906 (0.778)

     OD

0.070 ± 0.010

0.070 ± 0.010

−0.025 [0.090]

−0.20 | 0.15

0.833 (0.775)

−0.039 [0.090]

−0.21 | 0.13

0.879 (0.659)

Dorsal cingulum

 Overall diffusion

  

0.026 [0.070]

−0.11 | 0.16

0.944 (0.702)

0.025 [0.060]

−0.10 | 0.15

0.940 (0.703)

     AD

1.269 ± 0.057

1.274 ± 0.055

0.102 [0.090]

−0.07 | 0.28

0.454 (0.248)

0.101 [0.090]

−0.07 | 0.27

0.570 (0.243)

     FA

0.588 ± 0.045

0.591 ± 0.044

0.068 [0.090]

−0.10 | 0.24

0.664 (0.443)

0.067 [0.090]

−0.10 | 0.24

0.753 (0.441)

     MD

0.720 ± 0.025

0.722 ± 0.026

−0.068 [0.090]

−0.24 | 0.10

0.638 (0.444)

−0.069 [0.090]

−0.24 | 0.10

0.710 (0.430)

     RD

0.445 ± 0.038

0.445 ± 0.037

−0.012 [0.090]

−0.18 | 0.16

0.896 (0.896)

−0.012 [0.090]

−0.18 | 0.16

0.887 (0.887)

     ND

0.598 ± 0.033

0.598 ± 0.033

0.016 [0.090]

−0.16 | 0.19

0.898 (0.860)

0.015 [0.090]

−0.16 | 0.18

0.906 (0.866)

     OD

0.138 ± 0.018

0.138 ± 0.017

0.048 [0.090]

−0.12 | 0.22

0.833 (0.584)

0.048 [0.090]

−0.12 | 0.22

0.879 (0.584)

Ventral cingulum

 Overall diffusion

  

0.002 [0.060]

−0.11 | 0.11

0.968 (0.968)

0.004 [0.050]

−0.10 | 0.11

0.940 (0.940)

     AD

1.247 ± 0.082

1.255 ± 0.079

0.101 [0.090]

−0.07 | 0.27

0.454 (0.255)

0.103 [0.090]

−0.07 | 0.27

0.570 (0.240)

     FA

0.490 ± 0.0470

0.490 ± 0.044

0.001 [0.090]

−0.17 | 0.17

0.988 (0.988)

0.003 [0.090]

−0.17 | 0.17

0.997 (0.971)

     MD

0.745 ± 0.051

0.749 ± 0.044

−0.087 [0.090]

−0.26 | 0.09

0.638 (0.327)

−0.085 [0.090]

−0.26 | 0.09

0.710 (0.332)

     RD

0.49 ± 0.053

0.493 ± 0.047

−0.063 [0.090]

−0.24 | 0.11

0.608 (0.473)

−0.062 [0.090]

−0.23 | 0.11

0.720 (0.480)

     ND

0.508 ± 0.039

0.506 ± 0.035

−0.034 [0.090]

−0.21 | 0.14

0.898 (0.705)

−0.032 [0.090]

−0.20 | 0.14

0.906 (0.717)

     OD

0.166 ± 0.022

0.164 ± 0.022

0.095 [0.090]

−0.08 | 0.27

0.833 (0.283)

0.097 [0.090]

−0.07 | 0.27

0.879 (0.267)

Posterior thal rad

 Overall diffusion

  

−0.047 [0.060]

−0.16 | 0.06

0.905 (0.402)

−0.051 [0.060]

−0.16 | 0.06

0.940 (0.352)

     AD

1.370 ± 0.049

1.374 ± 0.045

0.086 [0.090]

−0.09 | 0.26

0.454 (0.332)

0.081 [0.090]

−0.09 | 0.25

0.570 (0.354)

     FA

0.607 ± 0.030

0.605 ± 0.031

−0.070 [0.090]

−0.24 | 0.10

0.664 (0.427)

−0.075 [0.090]

−0.25 | 0.10

0.753 (0.396)

     MD

0.771 ± 0.030

0.775 ± 0.029

−0.142 [0.090]

−0.32 | 0.03

0.638 (0.109)

−0.146 [0.090]

−0.32 | 0.03

0.710 (0.096)

     RD

0.465 ± 0.034

0.469 ± 0.035

−0.118 [0.090]

−0.29 | 0.06

0.603 (0.183)

−0.122 [0.090]

−0.29 | 0.05

0.690 (0.164)

     ND

0.569 ± 0.037

0.567 ± 0.036

−0.056 [0.090]

−0.23 | 0.12

0.898 (0.530)

−0.060 [0.090]

−0.23 | 0.11

0.906 (0.495)

     OD

0.119 ± 0.012

0.119 ± 0.012

0.019 [0.090]

−0.15 | 0.19

0.833 (0.833)

0.014 [0.090]

−0.16 | 0.19

0.879 (0.872)

Sag Stratum

 Overall diffusion

  

−0.012 [0.060]

−0.13 | 0.11

0.944 (0.839)

−0.009 [0.060]

−0.13 | 0.11

0.940 (0.886)

     AD

1.323 ± 0.046

1.329 ± 0.043

0.133 [0.090]

−0.04 | 0.31

0.454 (0.133)

0.136 [0.090]

−0.04 | 0.31

0.570 (0.125)

     FA

0.571 ± 0.031

0.570 ± 0.032

−0.004 [0.090]

−0.18 | 0.17

0.988 (0.965)

−0.000 [0.090]

−0.17 | 0.17

0.997 (0.997)

     MD

0.778 ± 0.027

0.781 ± 0.028

−0.124 [0.090]

−0.30 | 0.05

0.638 (0.160)

−0.121 [0.090]

−0.29 | 0.05

0.710 (0.174)

     RD

0.510 ± 0.034

0.513 ± 0.034

−0.067 [0.090]

−0.24 | 0.11

0.608 (0.449)

−0.063 [0.090]

−0.24 | 0.11

0.720 (0.475)

     ND

0.545 ± 0.034

0.542 ± 0.035

−0.061 [0.090]

−0.23 | 0.11

0.898 (0.492)

−0.057 [0.090]

−0.23 | 0.12

0.906 (0.520)

     OD

0.142 ± 0.013

0.141 ± 0.012

0.050 [0.090]

−0.12 | 0.22

0.833 (0.575)

0.053 [0.090]

−0.12 | 0.23

0.879 (0.550)

SLF

 Overall diffusion

  

−0.013 [0.060]

−0.13 | 0.11

0.944 (0.835)

−0.027 [0.060]

−0.15 | 0.09

0.940 (0.659)

     AD

1.117 ± 0.032

1.119 ± 0.034

0.082 [0.090]

−0.09 | 0.26

0.454 (0.353)

0.068 [0.090]

−0.10 | 0.24

0.570 (0.443)

     FA

0.512 ± 0.028

0.511 ± 0.026

−0.031 [0.090]

−0.20 | 0.14

0.936 (0.728)

−0.045 [0.090]

−0.22 | 0.13

0.784 (0.610)

     MD

0.693 ± 0.022

0.694 ± 0.022

−0.068 [0.090]

−0.24 | 0.10

0.638 (0.442)

−0.082 [0.090]

−0.26 | 0.09

0.710 (0.352)

     RD

0.480 ± 0.028

0.482 ± 0.026

−0.070 [0.090]

−0.24 | 0.10

0.608 (0.430)

−0.084 [0.090]

−0.26 | 0.09

0.720 (0.341)

     ND

0.672 ± 0.031

0.672 ± 0.031

−0.019 [0.090]

−0.19 | 0.15

0.898 (0.833)

−0.033 [0.090]

−0.21 | 0.14

0.906 (0.709)

     OD

0.196 ± 0.012

0.195 ± 0.013

0.028 [0.090]

−0.14 | 0.20

0.833 (0.753)

0.013 [0.090]

−0.16 | 0.19

0.879 (0.879)

uncF

 Overall diffusion

  

0.079 [0.060]

−0.05 | 0.21

0.905 (0.228)

0.072 [0.070]

−0.06 | 0.20

0.940 (0.272)

     AD

1.246 ± 0.061

1.248 ± 0.052

0.026 [0.090]

−0.15 | 0.20

0.864 (0.768)

0.020 [0.090]

−0.15 | 0.19

0.831 (0.825)

     FA

0.503 ± 0.049

0.508 ± 0.046

0.112 [0.090]

−0.06 | 0.28

0.664 (0.205)

0.106 [0.090]

−0.07 | 0.28

0.753 (0.234)

     MD

0.767 ± 0.033

0.765 ± 0.032

0.070 [0.090]

−0.10 | 0.24

0.638 (0.427)

0.064 [0.090]

−0.11 | 0.24

0.710 (0.473)

     RD

0.532 ± 0.045

0.527 ± 0.044

0.113 [0.090]

−0.06 | 0.29

0.603 (0.201)

0.107 [0.090]

−0.07 | 0.28

0.690 (0.230)

     ND

0.503 ± 0.032

0.506 ± 0.032

0.084 [0.090]

−0.09 | 0.26

0.898 (0.341)

0.078 [0.090]

−0.10 | 0.25

0.906 (0.382)

     OD

0.154 ± 0.019

0.152 ± 0.016

0.066 [0.090]

−0.11 | 0.24

0.833 (0.458)

0.059 [0.090]

−0.11 | 0.23

0.879 (0.506)

  1. Reported Tensor/NODDI measures are adjusted for site using Combat and Z-transformed. MD, RD and OD values are inverted so that higher values represent better microstructural integrity. False Discovery rate (FDR) significant differences are marked in bold. P < 0.05, uncorrected significant results are underlined. *Corrected for age, sex and education in years; FA fractional anisotropy, MD mean diffusivity, RD radial diffusivity, AD axial diffusivity, ND neurite density, OD orientation dispersion, SLF superior longitudinal fascicle, CC genu genu of the corpus callosum, CC body body of the corpus callosum, CC splenium splenium of the corpus callosum, uncF uncinate fascicle, Sag Stratum sagittal stratum, Posterior thal rad posterior thalamic radiation.
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