Fig. 2: Patterns of case-control differences in absolute gene expression across datasets.
From: Bipolar patients display stoichiometric imbalance of gene expression in post-mortem brain samples
a HC (green) and BD (yellow) gene expression, log2 RPKM residualised for covariates, for three example genes in all four data sets (nine outlier points are not shown in the plot). For SHANK2 (top) cases have higher observed expression than controls. For SP4 (middle), there is no pattern of difference between controls and cases, and for RASGRP1 (bottom) cases have lower observed expression than controls. b P values from the comparison between HC and BD mean residualised expression for all PGC3 associated genes for all four datasets (gene ordering identical to Fig. 3). Colours indicate direction of difference; red higher in BD and blue lower in BD (p value < 0.15). Small dots indicate nominal significance (p < 0.05) and large dots indicate significant p value (FDR < 0.05 across all genes and datasets). c same as (b)., but for the LIMMA-voom differential gene expression statistics.
