Fig. 5: Stoichiometric imbalance across genes and individuals.
From: Bipolar patients display stoichiometric imbalance of gene expression in post-mortem brain samples
a and b: SI score computation in CMC-HBCC. a Standardised, weighted scaled residuals averaged across iterations (\({{sWSR}}_{i,j}\)). Rows are genes sorted according to mean residuals in the BD set (with most deviant genes on top). Only the top 32 deviant genes are shown. Columns are samples sorted with increasing SI score. b Aggregation of each individual’s residuals across genes according to the SI score definition (Eq. (3)). c and d: Polygenic nature of BD aetiology with imbalanced defined as \(\left|{{{sWSR}}}_{{{i}}{l{,}}{{j}}}\right|{{ > }}{{2}}\). c Left: distribution of the number of imbalanced genes per healthy control. Median of CMC-HBCC density marked by vertical dotted line. Right: identical figure for BD cases. d Left: distribution of the fraction of imbalanced individuals (cases or controls) per gene for the 13 genes with significant coefficients in the logistic regression fitted with all four cortical datasets (Table S9). Right: identical figure for all genes ranked outside top 13.
