Table 1 Case-control brain RNAseq datasets in BD.

Dataset	Region	Samples		Mean age		Cauc.	Male	PMI	RIN	Mapped reads
		BD	HC	BD	HC
CMC-HBCC	DLPFC	71	165	42.6	43.1	50.0%	72.0%	28.0	7.7	103
CMC-Pitt	DLPFC	35	93	45.5	47.8	89.8%	66.1%	20.7	8.4	75.6
BrainGVEX SMRI	DLPFC	73	75	44.0	47.0	95.9%	66.2%	28.0	7.9	45.7
BipSeq sACC	sACC	125	142	42.5	50.5	100.0%	72.1%	27.0	7.7	110
BipSeq Amygdala	Amygdala	120	122	42.9	52.3	100.0%	70.8%	27.0	7.3	106
BrainGVEX BSHRI	DLPFC	0	184	NA	74.6	99.5%	58.7%	2.7	6.9	50.5

DLPFC dorsolateral prefrontal cortex, sACC subgenual anterior cingulate cortex, PMI Post mortem interval in median number of hours, RIN RNA integrity number, median across cohort samples.
All samples were prepared using rRNA depletion with stranded prep, with the exception of CMC-Pitt which was prepared unstranded. All samples were sequenced 100 bp paired-end.
BipSeq-Amygdala and BrainGVEX-BSHRI in italics as they were not used in this study (see methods).

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