Fig. 2: Interaction mechanism of 5-MeO-tryptamines at 5-HT receptors. | Molecular Psychiatry

Fig. 2: Interaction mechanism of 5-MeO-tryptamines at 5-HT receptors.

From: Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties

Fig. 2

a Ligand efficiency of the compounds when bound to 5-HT1AR or 5-HT2AR. b Binding pockets of 5-HT1AR (blue) and 5-HT2AR (purple). c Interaction between the indole scaffold and Thr121 of 5-MeO-DMT. d, e Predicted binding mechanism of 5-MeO-MET and 5-MeO-DIPT at 5-HT1AR. Green zones correspond to hydrophobic regions and purple zones correspond to hydrophilic regions within the pocket. f, g Spatial orientation of 5-MeO-MET and 5-MeO-DIPT in the 5-HT2AR pocket.

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