Fig. 3: Proposed inflamm-aging-associated mechanisms underlying the pathogenesis of psychosis and comorbidities. | Molecular Psychiatry

Fig. 3: Proposed inflamm-aging-associated mechanisms underlying the pathogenesis of psychosis and comorbidities.

From: Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?

Fig. 3: Proposed inflamm-aging-associated mechanisms underlying the pathogenesis of psychosis and comorbidities.

Inflamm-aging-like changes caused by genetic and epigenetic predisposition combined with environmental risk factors may play a central role in contributing to physical aging and brain aging, which leads to psychiatric disorders and commonly associated cardio-metabolic diseases in patients. HPA: Hypothalamus-pituitary gland-adrenal gland. blue arrows represent downregulation and red arrows indicate upregulation.

Back to article page