Fig. 5: Age-dependent increase of Tau pathology in 3xTg and Thy1-ApoE4/C/EBPβ Tg mice.
From: Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer’s disease
A Representative Tau PET images showing the Tau deposition in the brains of 3xTg and Thy1-ApoE4/C/EBPβ Tg mice at 2-, 6- and 12-month of age. 18F-AV1451 was used as a PET tracer of Tau aggregates. B Relative quantification of Tau PET standard uptake ratio (SUVR) in A (n = 3 mice, **p < 0.01, compared with Non Tg). C Representative of AT8 immunostaining images in the hippocampus of 3xTg and Thy1-ApoE4/C/EBPβ Tg mice at 2-, 6- and 12-month of age. The Non Tg mice have no AT8 signals at all ages. Scale bar, 20 μm. D Relative quantification of AT8 positive neurons in C. (n = 3 mice, *p < 0.05, **p < 0.01). E Co-staining of AT8 with ThS in the brains of 3xTg and Thy1-ApoE4/C/EBPβ Tg mice. Scale bar 20 μm. F Co-staining of AT8 with AV1451 in the brains of 3xTg and Thy1-ApoE4/C/EBPβ Tg mice. Scale bar 20 μm. G Levels of pTau181 and total Tau in the CSF of 3xTg (Top panels) and Thy1-ApoE4/C/EBPβ Tg mice (Bottom panels). (n = 3 mice, *p < 0.05, **p < 0.01).
