Fig. 2: The Single-cell opioid responses in the context of HIV (SCORCH) consortium.
From: The single-cell opioid responses in the context of HIV (SCORCH) consortium
A The SCORCH consortium will characterize the effects of SUD and HIV in the brain by elucidating the diversity of cell types (1) and cell type-specific molecular adaptations (2) via single-cell genomics in multiple brain regions of humans, non-human primates, and rodents. Key results will be validated through orthogonal approaches, including spatial transcriptomic profiling of brain tissues and genetic perturbation studies in human organoids and rodent models. (3). Data resources from these experiments will be publicly available through the SCORCH Data Center (4). B Data will be collected across 12 projects using brain tissue from humans, non-human primates, and rodent models. C Collectively, SCORCH researchers will investigate >15 brain regions relevant to SUD and HIV.
