Table 2 Cluster characteristics of regions showing significant correlations between ALFF and WM-evoked activity within the HC and MDD patients.

From: Aberrant associations between neuronal resting-state fluctuations and working memory-induced activity in major depressive disorder

Anatomical region

Number of voxels (27 mm3)

Peak Z-Statistics

MNI peak coordinates

x

y

z

Healthy controls

     

Positive correlation

     

MFG/IFG/prCG/SMA/AIC (l & r)

1845

6.85

30

8

55

IPL/SPL (l)

390

6.28

−42

−43

34

IPL/SPL (r)

365

5.61

33

−52

34

MOG/IOG/FG (l)

306

5.22

−39

−61

−5

Negative correlation

     

MPFC/ACC/SFG (l & r)

866

−5.34

−18

59

28

STG/SMG (r)

452

−6.04

48

−25

28

PCU/PCC/CU (l & r)

433

−5.26

−9

−58

10

AG (l)

171

−5.18

−42

−76

37

MDD patients

     

Positive correlation

     

MFG/IFG/prCG/SMA/AIC (r)

1499

6.09

36

2

61

MOG/IOG/FG (l & r)

1296

7.07

−30

−82

−2

MFG/IFG/prCG/SMA/AIC (l)

917

6.69

−36

−1

34

IPL/SPL (l)

840

6.33

−42

−37

34

IPL/SPL (r)

809

7.07

30

−40

37

Negative correlation

     

PCU/PCC/CU (l & r)

1294

−7.19

−15

−52

16

MPFC/ACC/SFG (l & r)

1015

−6.32

−12

50

−2

STG/SMG/poCG (r)

441

−5.59

48

−22

19

STG/SMG(l)

192

−5.13

−60

−31

31

AG (l)

168

−4.65

−42

−64

25

  1. Cluster-level threshold, p < 0.05 (GRF corrected); uncorrected single-voxel threshold of Z > 2.3. min cluster size HC = 80; min cluster size MDD = 108.
  2. MFG middle frontal gyrus, IFG inferior frontal gyrus, prCG precentral gyrus, SMA supplementary motor area, AIC anterior insular cortex, IPL inferior parietal lobule, SPL superior parietal lobule, MOG middle occipital gyrus, IOG inferior occipital gyrus, FG fusiform gyrus, MPFC medial prefrontal cortex, ACC anterior cingulate cortex, SFG superior frontal gyrus, STG superior temporal gyrus, SMG supramarginal gyrus, PCU precuneus, PCC posterior cingulate cortex, CU cuneus, AG angular gyrus, poCG postcentral gyrus.
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