Fig. 3: PSTNCrh neurons delay refeeding of familiar foods and increase consumption of novel palatable substances. | Molecular Psychiatry

Fig. 3: PSTNCrh neurons delay refeeding of familiar foods and increase consumption of novel palatable substances.

From: The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking

Fig. 3: PSTNCrh neurons delay refeeding of familiar foods and increase consumption of novel palatable substances.

A Experimental design and representative images of mCherry fluorescence illustrating expression of hM3Dq in PSTNCrh neurons (scale bars: gray, 500 μm; white, 200 μm). Behavioral testing was performed 30 min after injection of the chemogenetic actuator CNO or vehicle, and 24 h after food deprivation for chow (B) and Froot Loops (C, D), or 4 h after water deprivation for water (E) and sucrose (F, G). Testing was performed upon first-time access to Froot Loops and sucrose (C, F) and again following habituation (D, G). In each panel, the latency to initiate feeding/drinking is shown on the left and the amount of food/fluid consumed is shown on the right. Bars represent mean ± s.e.m. and individual values are overlaid. Data were analyzed using unpaired t tests, *p < 0.05; **p < 0.01.

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