Fig. 2: Serotonin (5-HT) synthesis in the ventral striatum (VStr, top row) and anterior insula (bottom row).
From: Dynamics of human serotonin synthesis differentially link to reward anticipation and feedback
a Baseline serotonin synthesis as obtained with [11C]AMT. b Regions of interest indicate the anatomical definition of the VStr of the Harvard-Oxford atlas (“nucleus accumbens” marked in blue, top) and the anterior insula as obtained from the voxel wise analysis on task-specific changes in 5-HT synthesis (p < 0.05 FWE corrected cluster level, t-values in red-yellow, bottom). c Reward-specific changes extracted from the regions of interest (b) of the VStr (top) and anterior insula (bottom) during monetary gain (blue) and loss (red). There was no significant difference between monetary gain or loss (all p > 0.2). Axial and coronal slices (a, b) are shown at z = 3/13 mm and y = 8/14 mm MNI space, respectively. Boxplots (c) indicate median values (center line), upper and lower quartiles (box limits) and 1.5*interquartile range (whiskers).
