Fig. 5: Cerebellar clusters covary negatively with mean positive facial action unit activity. | Molecular Psychiatry

Fig. 5: Cerebellar clusters covary negatively with mean positive facial action unit activity.

From: Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli

Fig. 5: Cerebellar clusters covary negatively with mean positive facial action unit activity.

A Two clusters in the cerebellum that covaried negatively with mean positive facial action unit activity (i.e., the higher the activity of facial muscles involved in the display of positive affect, the lower the fMRI signal in these clusters). B The largest cluster was found in the left posterior cerebellar hemisphere, where we detected a significant difference in this relationship between participants with melancholic and non-melancholic depression (analysis of covariance F = 4.11, p = 0.047). Clinical characteristics and data quality were reviewed for all participants and there were no discrepancies amongst variables such as clinical status, medication use, head motion, normalisation or whole-brain coverage for any participants. All data points were within 2.5 standard deviations of the group mean for melancholic and non-melancholic participants.

Back to article page