Table 1 Characteristics of the study cohort.
Characteristics | Total (n = 70) | Melancholic (n = 30) | Non-melancholic (n = 40) |
|---|---|---|---|
Sex (percent) | |||
Male | 28 (40.0) | 14 (46.7) | 14 (35.0) |
Female | 42 (60.0) | 16 (53.3) | 26 (65.0) |
Age in years (mean (SD), median (range)) | 44.0 (±12.8), 46 (24–65) | 44.7 (±13.3), 46 (24–65) | 43.4 (±12.5), 45 (24–65) |
Body mass index (mean (SD), median (range)) | 28.5 (±6.2), 28 (18–46) | 29.0 (±6.5), 28 (18–44) | 28.1 (±6.0), 28 (19–46) |
Age depression onset (mean (SD), median (range)) | 18.6 (±9.9), 16 (5–48) | 19.9 (±10.3), 17 (5–46) | 17.5 (±9.7), 16 (5–48) |
Antidepressant trials (mean (SD), median (range)) | 4.8 (±3.2), 4 (0–13) | 5.6 (±3.3), 6 (0–13) | 4.2 (±2.9), 4 (1–12) |
MADRS (mean (SD), median (range)) | 25.3 (±10.1), 25 (6–44) | 29.6 (±10.1), 34 (8–44) | 22.0 (±8.9), 23 (6–42)* |
MADRS sleep (mean (SD), median (range)) | 2.7 (±1.7), 3 (0–6) | 3.3 (±1.6), 4 (0–6) | 2.2 (±1.7), 2 (0–5)* |
MADRS appetite (mean (SD), median (range)) | 1.1 (±1.6), 0 (0–5) | 1.7 (±1.7), 0 (0–5) | 0.7 (±1.3), 0 (0–5)* |
MADRS feeling (mean (SD), median (range)) | 2.8 (±1.6), 3 (0–5) | 2.8 (±1.5), 3 (0–5) | 1.7 (±1.4), 2 (0–5)* |
HAM-A (mean (SD), median (range)) | 20.1 (±8.6), 20 (4–45) | 22.2 (±7.6), 23 (4–39) | 18.5 (±8.9), 19 (5–45) |
SHAPS (mean (SD), median (range)) | 5.6 (±4.2), 6 (0–14) | 7.4 (±4.0), 8 (0–14) | 4.2 (±3.8), 3 (0–13)* |
Antidepressant use | 55 | 26 | 29 |
Fluoxetine equivalent dose (mg) (mean (SD), median (range)) | 36.1 (±30.6), 40 (0–118) | 41.4 (±31.7), 40 (0–118) | 31.9 (±29.4), 22.2(0–95.7) |
Antipsychotic use | 11 | 7 | 4 |
Risperidone equivalent dose (mg) (mean (SD), median (range)) | 0.2 (±0.7), 0 (0–5) | 0.4 (±1.0), 0 (0–5) | 0.1 (±0.4), 0 (0–2) |
Mood stabiliser use | 3 | 1 | 2 |
Benzodiazepine use | 4 | 2 | 2 |
Stimulant use | 8 | 4 | 4 |
Education level (percent) | |||
Primary school | 1 (1.4) | 1 (3.3) | 0 (0) |
Junior high school | 7 (10.0) | 3 (10.0) | 4 (10.0) |
High school | 6 (8.6) | 4 (13.3) | 2 (5.0) |
Diploma | 11 (15.7) | 8 (26.7) | 3 (7.5) |
University degree | 28 (40.0) | 8 (26.7) | 20 (50.0) |
Postgraduate degree | 17 (24.3) | 6 (20.0) | 11 (27.5) |
Alcohol use (last 3 months) (percent) | |||
Never | 23 (32.9) | 11 (36.6) | 12 (30.0) |
Once or twice | 11 (15.7) | 6 (20.0) | 5 (12.5) |
Monthly | 7 (10.0) | 0 (0) | 7 (17.5) |
Weekly | 14 (20.0) | 7 (23.3) | 7 (17.5) |
Daily | 15 (21.4) | 6 (20.0) | 9 (22.5) |
Tobacco use (last 3 months) (percent) | |||
Never | 61 (87.1) | 28 (93.3) | 33 (82.5) |
Once or twice | 2 (2.9) | 0 (0) | 2 (5.0) |
Monthly | 0 (0) | 0 (0) | 0 (0) |
Weekly | 0 (0) | 0 (0) | 0 (0) |
Daily | 7 (10.0) | 2 (6.6) | 5 (12.5) |
Employment status (percent) | |||
Full time | 37 (52.9) | 15 (50.0) | 22 (55.0) |
Part time | 9 (12.9) | 2 (6.7) | 7 (17.5) |
Unemployed | 22 (31.4) | 12 (40.0) | 10 (25.0) |
Retired | 2 (2.9) | 1 (3.3) | 1 (2.5) |
Developmental vulnerabilities (percent) | |||
Attachment disorder | 31 (44.3) | 11 (36.7) | 20 (50.0) |
Physical abuse | 14 (20.0) | 2 (6.7) | 12 (30.0) |
Sexual abuse | 16 (22.9) | 8 (26.7) | 8 (20.0) |
Bullying | 25 (35.7) | 12 (40.0) | 13 (32.5) |
Domestic violence | 15 (21.4) | 6 (20.0) | 9 (22.5) |
