Fig. 2: Treatment effect on cue-induced activation in the left and right NAc. | Molecular Psychiatry

Fig. 2: Treatment effect on cue-induced activation in the left and right NAc.

From: Acute cannabidiol administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial

Fig. 2: Treatment effect on cue-induced activation in the left and right NAc.

Depiction of A the activation clusters in the left and right nucleus accumbens (NAc), which showed a significant treatment effect with significantly lower cue-induced activation in the CBD group (n = 12) compared to the PLC group (n = 13) (pFWE < 0.05 small volume corrected for the NAc as pre-specified region of interest; boundaries of the region of interest mask are plotted as red and blue lines) and B the significant difference in mean alcohol cue-induced brain activation in the left and right NAc between the CBD and PLC groups (as part of a post hoc test, mean activation for the contrast “alcohol – neutral” was extracted using the pre-specified region of interest mask for the NAc and the marsbar toolbox for Matlab).

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