Fig. 2: Social interaction preference and selected ICA findings of CON, SUS, and RES mouse groups. | Molecular Psychiatry

Fig. 2: Social interaction preference and selected ICA findings of CON, SUS, and RES mouse groups.

From: Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain

Fig. 2

A-left) Representation of social interaction (SI) ratios (mean ± SEM) from undefeated control mice (CON, n = 18) as well as defeated ‘susceptible’ (SUS, n = 20) and ‘resilient’ (RES, n = 6) mouse groups. SI ratios were calculated as time spent in the interaction zone when the CD1 attacker was absent divided by the time spent in the interaction zone when the CD1 attacker was present. SUS mice scored significantly lower in SI ratio compared to both CON and RES mouse groups (***p < 0.0001). A data point from the CON mouse group is highlighted (encircled-yellow) as an outlier but was not excluded from analyses (Supplementary Figure S2). A-right) Representation of time spent in the interaction zone (mean ± SEM)—with the CD1 attacker mouse present—from identified mouse groups. SUS mice spend significantly less time in the interaction zone (when the CD1 attacker is present) compared to both CON (***p < 0.0001) and RES (*p < 0.05) mouse groups. B Selected findings from low component [20] spatial ICA performed on rs-fMRI data from individual mouse groups (left, CON; middle, SUS; right, RES) identify four common stress-related components in all animals; specifically, the ACA, NAc, BLA, and vDG regions. Prominent components are overlaid on corresponding template coronal brain slices in identified mouse groups. ACA anterior cingulate area, AUD auditory area, BLA basolateral amygdala, CON control, CP caudate putamen, MO somatomotor area, NAc nucleus accumbens, Pir piriform area, RES resilient, SS somatosensory area, SUS susceptible, Th thalamus, vDG ventral dentate gyrus, VIS visual area.

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