Fig. 6: Quantification of vDG (top) seed-voxel FC with selected brain regions.

A 3D representations of a manually generated vDG (top) source seed (A-left) and 5 selected target regions (A-right) overlaid on Allen Mouse Brain Connectivity Atlas (2011) whole brain images. B–D Schematic illustrations outline a quantification of significant vDG seed-voxel FC findings from Fig. 4 with selected target regions between SUS versus CON (B), RES versus CON (C), and SUS versus RES (D) mouse groups. SUS mice show preferential FC between the vDG and subcortical regions with the strongest change between the vDG and VTA regions when compared to RES mice (41.79%). Prominent vDG FC with the ACA region is favoured in CON mice compared to both RES (3.03%) and SUS (9.89%) mouse groups; however, RES mice show the largest FC change between the vDG and ACA (27.32%) relative to SUS animals. Left panels indicate the percent of voxels within a specified target region that showed a significant FC group difference with the vDG source seed. The magnitude of this percentage is represented by the line thickness (yellow connectivity bar). Right panels indicate the number of voxels within a specified target region that show a significant change in vDG FC. The black-white colour scaling bar (right) indicates the total number of significant voxels. Green-coloured spheres indicate the anatomical location of the vDG region. The direction of group differences between the vDG and target regions is represented by a red or blue coloured sphere. Regions with no group difference are indicated by a grey-coloured sphere. ACA anterior cingulate area, BLA basolateral amygdala, CON control, NAc nucleus accumbens, PAG periaqueductal gray area, RES resilient, SUS susceptible, vDG ventral dentate gyrus, VTA ventral tegmental area.