Fig. 4: GWAS results for total heroin consumed across self-administration training. | Molecular Psychiatry

Fig. 4: GWAS results for total heroin consumed across self-administration training.

From: Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats

Fig. 4: GWAS results for total heroin consumed across self-administration training.

a Regional association plot for chromosome 11, with the purple dot indicating the top SNP and location on chromosome indicated on the plot. The color of additional SNPS refers to extent of linkage disequilibrium with the top SNP. Known genes of SNPs are indicated below the plots. b Effect plots for total heroin consumption during training (left: normalized data; right: raw data) for OUD phenotypes (Vulnerable: pink; Intermediate/resilient: yellow) according to peak SNP allelic variant. Half of a violin plot for each phenotype is shown, with the solid line indicating the median value of the data and the dash lines representing the upper and lower interquartile range. c Top SNP allelic variant OUD phenotype cluster composition differ (x2(1, 853) = 18.12, p < 0.0001), with the minor allele associated with greater OUD resiliency. Significance threshold: red line, p < 0.10; blue line, p < 0.05. (n = 853; Vulnerable (pink), n = 361; Intermediate/resilient (yellow), n = 492).

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