Fig. 5: Somatic and dendritic releasing synapses share the same properties. | Molecular Psychiatry

Fig. 5: Somatic and dendritic releasing synapses share the same properties.

From: Coding principles and mechanisms of serotonergic transmission modes

Fig. 5

A Snapshots and 3D spatiotemporal profiling of electrically evoked fluorescence ΔF/F0 responses in the CeA. Note the isolated releasing synapses on the soma and dendrite indicated by pink and green arrows, respectively. B ΔF/F0 responses evoked by single pulse stimuli at isolated releasing synapses on the soma (pink) and dendrite (green). C–D 10–90% rise times (Soma: 0.24 ± 0.03 s; Dendrite: 0.19 ± 0.03 s; U = 33.50, p = 0.23) and decay time constants (Soma: 8.35 ± 0.81 s; Dendrite: 7.11 ± 1.00 s; U = 40.00, p = 0.47) of ΔF/F0 responses. E–G Average (Soma: 1.37 ± 0.06; Dendrite: 1.27 ± 0.04; U = 33.00, p = 0.21) and maximal (Soma: 2.20 ± 0.13; Dendrite: 2.20 ± 0.13; U = 50.00, p = 0.96) vesicular quanta, quantal sizes (Soma: 0.40 ± 0.03%; Dendrite: 0.44 ± 0.06%; U = 56.50, p = 0.65), and release probabilities (Soma: 78.00 ± 4.00%; Dendrite: 81.40 ± 3.47%; U = 59.5, p = 0.50) on the soma (green) and dendrite (cyan). Note n.s. indicates no statistical difference (p > 0.05; n = 10 neurons from 5 animals; Rank Sum non-parametric tests).

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