Table 2 Buccal CpGs significantly associated (alpha = 2.7 × 10−5) with maternal, paternal, or offspring polygenic scores for schizophrenia, educational attainment (EA), body mass index (BMI), and height.
From: Intergenerational transmission of complex traits and the offspring methylome
PGS | CpG | CHR:BPa | Geneb | mQTLs | SNPs | Complex traits |
|---|---|---|---|---|---|---|
Maternal Schizophrenia | cg00974944 | 3:61649924 | PTPRG | |||
Maternal Schizophrenia | cg02039858 | 14:65828769 | ||||
Maternal Schizophrenia | cg03174043 | 2:20548412 | 185 | fractional exhaled nitric oxide | ||
Maternal Schizophrenia | cg03526788 | 8:130899478 | FAM49B | |||
Maternal Schizophrenia | cg04822154 | 8:124692680 | ||||
Maternal Schizophrenia | cg07980854 | 20:57586338 | 634 | breast cancer; type 2 diabetes; atopy; psoriasis | ||
Maternal Schizophrenia | cg09163778 | 6:31125417 | TCF19; CCHCR1 | |||
Maternal Schizophrenia | cg10365572 | 5:141245930 | PCDH1 | |||
Maternal Schizophrenia | cg12098069 | 13:42537172 | VWA8-AS1 | |||
Maternal Schizophrenia | cg12501870 | 8:81803721 | 182 | |||
Maternal Schizophrenia | cg12759387 | 1:27849177 | 177 | systemic lupus erythematosus; polychlorinated biphenyls exposure | ||
Maternal Schizophrenia | cg21028402 | 6:113932902 | 297 | helicobacter pylori infection; oral squamous cell carcinoma | ||
Maternal Schizophrenia | cg22280238 | 17:79251323 | SLC38A10 | |||
Maternal Schizophrenia | cg26017484 | 1:3322309 | PRDM16 | adenoma | ||
Maternal Schizophrenia | cg27277458 | 10:63597194 | ||||
Paternal Schizophrenia | cg02838980 | 16:10402487 | ||||
Offspring Schizophrenia | cg01229327 | 19:54311998 | NLRP12 | |||
Offspring Schizophrenia | cg02530860 | 8:144371537 | 646 | gender; sperm viability; assisted reproduction technology; infant sex; sexually dimorphic | ||
Offspring Schizophrenia | cg03161422 | 4:175256045 | ||||
Offspring Schizophrenia | cg03836484 | 10:25349182 | ENKUR | |||
Offspring Schizophrenia | cg09950681 | 11:393392 | PKP3 | |||
Offspring Schizophrenia | cg09967523 | 18:18943072 | GREB1L | |||
Offspring Schizophrenia | cg12381295 | 20:3880297 | PANK2 | gingivo-buccal oral squamous cell carcinoma (OSCC-GB) | ||
Offspring Schizophrenia | cg12614148 | 1:118325026 | 98 | |||
Offspring Schizophrenia | cg12823387 | 1:214614656 | PTPN14 | |||
Offspring Schizophrenia | cg15518113 | 1:167400121 | CD247 | 105 | Air pollution (NO2); adrenocortical carcinoma; smoking; multiple sclerosis; | |
Offspring Schizophrenia | cg15571646 | 2:238767351 | RAMP1 | |||
Offspring Schizophrenia | cg16739178 | 16:85470674 | 50 | papillary thyroid carcinoma; aging; BMI; Crohn’s disease; Behcet’s disease; maternal hypertensive disorders in pregnancy; gestational age; blood C-reactive protein level; inflammatory bowel disease | ||
Offspring Schizophrenia | cg17727125 | 8:38441156 | ||||
Offspring Schizophrenia | cg20516845 | 21:43823604 | UBASH3A | 140 | ||
Offspring Schizophrenia | cg20742175 | 20:57267357 | NPEPL1; STX16-NPEPL1 | high risk cutaneous squamous cell carcinoma (cSCC) | ||
Offspring Schizophrenia | cg20807751 | 9:84025287 | ||||
Offspring Schizophrenia | cg22889887 | 11:113433931 | 6 | |||
Offspring Schizophrenia | cg23464619 | 13:95513506 | 50 | hepatocellular carcinoma; colorectal laterally spreading tumor; inflammatory bowel disease; ulcerative colitis | ||
Offspring Schizophrenia | cg24812103 | 8:101735630 | PABPC1 | 244 | prenatal arsenic exposure; gestational diabetes mellitus; inflammatory bowel disease | |
Offspring Schizophrenia | cg25607267 | 12:122362708 | WDR66 | |||
Offspring Schizophrenia | cg27475979 | 16:89471039 | ANKRD11 | |||
Paternal EA | cg14576502 | 8:102962279 | NCALD | recurrent adult-type IDH-mutant gliomas | ||
Paternal EA | cg15336177 | 1:99369228 | LPPR5 | |||
Offspring EA | cg04975399 | 1:67822225 | IL12RB2 | fractional exhaled nitric oxide | ||
Offspring EA | cg05083647 | 1:204897364 | NFASC | |||
Offspring EA | cg06629713 | 2:60580559 | 43 | primary Sjogren’s Syndrome; obesity; Type 2 diabetes; asthma; atopy; Crohn’s disease; fractional exhaled nitric oxide; hepatitis B virus-related liver disease progression | ||
Maternal BMI | cg06565683 | 20:46817989 | ||||
Maternal Height | cg21894669 | 2:165379442 | GRB14 | |||
Maternal Height | cg22338356 | 8:48739161 | PRKDC | Down Syndrome; Fetal alcohol spectrum disorder | ||
Paternal Height | cg01633359 | 5:33439359 | 164 | 56 | ||
Paternal Height | cg03338154 | 6:41121714 | TREML1 | |||
Paternal Height | cg12738049 | 15:76509692 | ETFA | |||
Paternal Height | cg23975250 | 22:44757380 | sexually dimorphic | |||
Offspring Height | cg02319662 | 4:108127694 | ||||
Offspring Height | cg03480605 | 7:151038446 | NUB1 | 216 | 17 | maternal smoking; obesity; oral squamous cell carcinoma |
