Fig. 4: SBI-0646535 has a unique spectral profile compared to OLZ in all groups.

All data are shown as a group mean ( ± SEM). Full spectrum data are presented in 1 Hz bins expressed as the average percent change from baseline during the 30–150 min post-dosing period. Gray vertical bars represent frequency bands (delta, Δ 0.5–4 Hz; theta, θ 4–8 Hz; alpha, α 8–13 Hz; sigma, σ 13–15 Hz; beta, β 13–30 Hz; low gamma, γ 30–50 Hz; high gamma, γ 50–100 Hz). All tested OLZ doses were examined within each individual group: O-I (n = 9) (A), Ovx (n = 9) (B), and Ovx+E rats (n = 9) (C). All tested SBI-0646535 doses were also examined within each group: O-I (n = 8) (D), Ovx (n = 7–9) (E), and Ovx+E (n = 7–9) (F). p < 0.05; horizontal colored lines matching the color of respective doses represent frequencies at which OLZ- or SBI-0646535-treated groups were significantly different from vehicle-treated groups.