Fig. 6: OLZ, but not SBI-0646535, reduced MK-801-induced increases in locomotor activity. | Molecular Psychiatry

Fig. 6: OLZ, but not SBI-0646535, reduced MK-801-induced increases in locomotor activity.

From: 17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats

Fig. 6: OLZ, but not SBI-0646535, reduced MK-801-induced increases in locomotor activity.The alternative text for this image may have been generated using AI.

For direct group comparisons, each individual’s locomotor activity counts were summed in the 30–90 min post-dosing period for MK-801 (main effect of dose: F1.422, 39.46 = 67.00; p < 0.0001) (A) or 60–180 min post dosing period for OLZ (main effect of dose: F1.943, 39.82 = 11.79, p = 0.0001) (B) or SBI-0636535 (C) combinations with MK-801 and graphed as a group mean ± SEM. p < 0.05; a, compared to group’s respective vehicle condition. For MK-801, n = 9–10 O-I, 8–9 Ovx, and 12 Ovx+E rats. For OLZ and SBI-0646535 combinations, n = 8 O-I, 7–8 Ovx, and 8 Ovx+E rats.

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