Fig. 7: Altered endocytosis in microglia is supported by transcriptomic data from human ASD brain tissue. | Molecular Psychiatry

Fig. 7: Altered endocytosis in microglia is supported by transcriptomic data from human ASD brain tissue.

From: CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning

Fig. 7: Altered endocytosis in microglia is supported by transcriptomic data from human ASD brain tissue.The alt text for this image may have been generated using AI.

A Volcano plot showing the change in expression as measured by single cell RNA-sequencing for differentially expressed genes (DEGs) in microglia from postmortem tissue from individuals with ASD compared to neurotypical controls [37] (DEGs, Benjamini & Hochberg corrected p values < 0.01). B GO Cellular Component enrichment analysis of DEGs with increased expression in microglia from postmortem tissue from individuals with ASD. Terms representing unique gene sets and with Padj < 0.05 are displayed. Terms are color-coded such that terms of the same color have many overlapping genes. C Summary model of microglial phenotypes with ADNP loss.

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