Table 2 Differences between identified FTD clusters in GMV and sulcal depth.

From: Transdiagnostic types of formal thought disorder and their association with gray matter brain structure: a model-based cluster analytic approach

 

H

x

y

z

t

k

p FWE cluster-level

p inter-action analyses

Partial. η²

GMV

cluster 1 (minimal overall FTD) > cluster 4 (severe overall FTD)

55.5% superior frontal gyrus

44.5% medial frontal gyrus

R

12

42

38

3.99

800

0.048

0.404

0.022

cluster 3 (inhibition) > cluster 1 (minimal overall FTD)

50.8% inferior temporal gyrus

19.5% fusiform gyrus

18.2% middle temporal gyrus

R

42

−3

−34

4.93

926

0.029

0.060

0.027

cluster 3 (inhibition) > cluster 4 (severe overall FTD)

85.6% inferior temporal gyrus

11.5% middle temporal gyrus

2.9% fusiform gyrus

R

48

−9

−36

4.45

2404

<0.0001

0.063

0.020

Sulcal depth

cluster 3 (inhibition) > cluster 2 (poverty)

45% insula

37% superior temporal sulcus

16% temporal pole

L

−36

1

−22

3.97

238

0.004

0.145

0.019

cluster 3 (inhibition) > cluster 4 (severe overall FTD)

100% insula

R

40

5

−2

3.57

287

0.001

0.778

0.009

100% insula

L

−39

2

−7

3.31

188

0.001

0.667

0.005

  1. Note: Interaction analyses refer to the post-hoc investigation of clinical DSM diagnoses on brain structural differences between FTD clusters. Therefore, an ANCOVA design in R with the clinical DSM diagnosis and cluster membership as factors and significant clusters from VBM and SBM as dependent variables were used. R right, L left, H hemisphere; FWE Family-Wise-Error; k cluster extend; bold letters indicate significance after correction for multiple testing (Benjamini Hochberg).