Fig. 3: M1/M4 receptor density is decreased in schizophrenia in the striatum, hippocampus and the fronto-cingulate cortex. | Molecular Psychiatry

Fig. 3: M1/M4 receptor density is decreased in schizophrenia in the striatum, hippocampus and the fronto-cingulate cortex.

From: Cholinergic system in schizophrenia: A systematic review and meta-analysis

Fig. 3: M1/M4 receptor density is decreased in schizophrenia in the striatum, hippocampus and the fronto-cingulate cortex.The alternative text for this image may have been generated using AI.

Forest plots of Random Effect (RE) meta-analyses of [3H]pirenzepine binding assays, representing M1/M4 receptor density, in the post-mortem (a) striatum, (b) hippocampus, and (c) fronto-cingulate cortex of individuals with schizophrenia relative to controls. Percent contribution to pooled effect size (Hedge’s g) shown as a square. Whiskers show confidence intervals (95%). For the meta-analysis in fronto-cingulate cortex (c), Zavitsanou and colleagues (2004) assessed anterior cingulate region and the other three studies assessed Brodmann Area 9.

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