Table 1 Descriptive characteristics of the three relative cohorts.
Cohorts | Variables | Overall | Men | Women |
|---|---|---|---|---|
Index persons | No. | 3,332,608 | 1,712,340 (51.38%) | 1,620,268 (48.62%) |
Autism, n (%) | 88,343 (2.65%) | 57,619 (3.36%) | 30,724 (1.90%) | |
Intellectual disability, n (%) | 37,321 (1.12%) | 22,330 (1.30%) | 14,991 (0.93%) | |
Diagnosis age of autism, median (IQR) | 15 (10, 20) | 13 (9, 19) | 16 (12, 21) | |
Diagnosis age of ID, median (IQR) | 12 (7, 17) | 11 (7, 16) | 13 (7, 18) | |
Parents | No. of relative pairs | 3,622,241 | 1,886,705 (52.09%) | 1,735,536 (47.91%) |
No. of relatives | 1,802,180 | 937,591 (52.03%) | 864,589 (47.97%) | |
Age by the end of study, median (IQR) | 61 (56, 67) | 62 (56, 69) | 60 (55, 66) | |
Any dementia, n (%) | 11,879 (0.66%) | 7932 (0.85%) | 3947 (0.46%) | |
Alzheimer’s disease n (%) | 9326 (0.52%) | 6020 (0.64%) | 3306 (0.38%) | |
Other dementia, n (%) | 4588 (0.25%) | 3435 (0.37%) | 1153 (0.13%) | |
Any dementia, n (%)b | 14,244 (0.79%) | 9440 (1.01%) | 4804 (0.56%) | |
Alzheimer’s disease n (%)b | 12,573 (0.70%) | 8208 (0.88%) | 4365 (0.50%) | |
Onset age of any dementia, median (IQR) | 66 (60, 71) | 67 (61, 72) | 63 (57, 68) | |
Onset age of AD, median (IQR) | 66 (60, 71) | 67 (61, 73) | 63 (58, 68) | |
Onset age of other dementia, median (IQR) | 66 (61, 71) | 67 (62, 72) | 63 (57, 67) | |
Onset age of any dementia, median (IQR)a | 69 (62, 74) | 70 (64, 75) | 66 (60, 71) | |
Onset age of AD, median (IQR)a | 69 (63, 74) | 71 (64, 76) | 66 (60, 71) | |
Onset age of other dementia, median (IQR)a | 69 (63, 74) | 70 (65, 75) | 65 (60, 70) | |
Grandparents | No. of unique pairs | 10,056,113 | 4,985,137 (49.57%) | 5,070,976 (50.43%) |
No. of relatives | 3,032,259 | 1,499,774 (49.46%) | 1,532,485 (50.54%) | |
Age by the end of study, median (IQR) | 84 (74, 96) | 85 (75, 98) | 82 (72, 95) | |
Any dementia, n (%) | 296,244 (9.77%) | 128,202 (8.55%) | 168,042 (10.97%) | |
Alzheimer’s disease, n (%) | 256,489 (8.46%) | 107,422 (7.16%) | 149,067 (9.73%) | |
Other dementia, n (%) | 86,370 (2.85%) | 43,735 (2.92%) | 42,635 (2.78%) | |
Any dementia, n (%)b | 320,272 (10.56%) | 138,046 (9.20%) | 182,226 (11.89%) | |
Alzheimer’s disease, n (%)b | 288,076 (9.50%) | 121,339 (8.09%) | 166,737 (10.88%) | |
Onset age of any dementia, median (IQR) | 79 (74, 84) | 78 (73, 83) | 80 (74, 85) | |
Onset age of AD, median (IQR) | 79 (74, 84) | 78 (73, 83) | 80 (75, 85) | |
Onset age of other dementia, median (IQR) | 78 (73, 83) | 77 (72, 82) | 79 (74, 84) | |
Onset age of any dementia, median (IQR)a | 83 (77, 88) | 82 (76, 86) | 84 (78, 88) | |
Onset age of AD, median (IQR)a | 83 (77, 88) | 82 (77, 87) | 84 (78, 89) | |
Onset age of other dementia, median (IQR)a | 82 (76, 87) | 80 (75, 85) | 83 (77, 88) | |
Aunts/uncles | No. of unique pairs | 2738,562 | 1,345,089 (49.12%) | 1,393,473 (50.88%) |
No. of relatives | 1,208,371 | 592,419 (49.02%) | 615,952 (50.97%) | |
Age by the end of study, median (IQR) | 62 (56, 69) | 62 (56, 69) | 62 (56, 69) | |
Any dementia, n (%) | 10,486 (0.87%) | 5247 (0.89%) | 5239 (0.85%) | |
AD, n (%) | 8443 (0.70%) | 4001 (0.68%) | 4442 (0.72%) | |
Other dementia, n (%) | 3669 (0.30%) | 2194 (0.37%) | 1475 (0.24%) | |
Any dementia, n (%)b | 12,772 (1.06%) | 6348 (1.07%) | 6424 (1.04%) | |
AD, n (%)b | 11,455 (0.95%) | 5566 (0.94%) | 5889 (0.96%) | |
Onset age of any dementia, median (IQR) | 67 (62, 72) | 67 (62, 72) | 68 (61, 72) | |
Onset age of AD, median (IQR) | 68 (62, 72) | 68 (62, 73) | 68 (62, 72) | |
Onset age of other dementia, median (IQR) | 67 (62, 72) | 67 (62, 72) | 67 (61, 72) | |
Onset age of any dementia, median (IQR)a | 71 (64, 76) | 70 (65, 75) | 71 (64, 76) | |
Onset age of AD, median (IQR)a | 71 (65, 76) | 71 (65, 76) | 71 (65, 76) | |
Onset age of other dementia, median (IQR)a | 70 (64, 75) | 70 (65, 75) | 70 (64, 76) |
