Table 1 Variants in non-coding RNA and their targets.

From: Deep learning algorithms reveal genomic markers for anxiety disorder in a large cohort of children with down syndrome

Mutations

ncRNA with exonic variants

Regulatory targets

Target gene function

chr6:30291803-T-G

HCG18

FGFR1

Involved in multiple mental disorders, including depression, bipolar disorder, and schizophrenia

chr5:43573385-A-G; chr5:43573453-CAAAG-C; chr5:43573599-G-A; chr5:43574087-T-C; chr5:43574806-C-G; chr5:43602972-C-T

NNT-AS1

SMAD4

Gene expression altered in the blood and brain of schizophrenia patients

chr21:43809225-C-G; chr21:43811039-C-T; chr21:43811979-C-T; chr21:43812406-G-A

AATBC

NFE2L2

Involved in the oxidative stress and psychiatric disorders and a potential therapeutic target

chr18:1276085-A-G

LINC00470

ILF3

Significantly associated with the risk of bipolar disorder

chr4:1218202-G-A

CTBP1-AS

miR-940

Differentially expressed in major depression disorders

chr21:20781609-C-T

LINC00320

CTNNB1

Mutations of CTNNB1 lead to dysfunction in the Wnt signaling pathway, which regulates gene transcription and further disturbs synaptic plasticity, neuronal apoptosis, and neurogenesis.

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