Table 3 Anxiety-specific markers in DS population.

From: Deep learning algorithms reveal genomic markers for anxiety disorder in a large cohort of children with down syndrome

gene

Locus

Variation details

Weight for phenotype matrix

Weight (anxiety)

Weight (other mental disorders)

Log2(fold changes) based on RNA-seq

C20orf204

5′ UTR

chr20:64034829-G-A;chr20:64035936-G-A

0.008

0.241

−0.572

0.094

SS18L1

synonymous

SS18L1:exon7|chr20:62164215-G-A|

0.005

0.329

−0.389

0.117

CCK

5′ UTR

chr3:42263846-C-T

0.004

0.197

−0.425

NA

KRT7

nonsynonymous

KRT7:exon9|chr12:52248642-C-T|

0.004

0.141

−0.122

−1.324

FBXL13

synonymous

FBXL13:exon19|chr7:102813465-A-G|

0.003

0.136

−0.264

−0.032

DMXL2

intronic

chr15:51603605-G-A

0.003

0.169

−0.199

0.200

ARG2

synonymous

ARG2:exon3|chr14:67642245-TACA-T|

0.003

0.105

−0.269

0.195

STK11IP

intronic

chr2:219606626-T-C

0.003

1.269

−0.499

0.188

CAMSAP3

intronic

chr19:7611513-C-T

0.003

0.106

−0.205

−0.347

MAFA

5′ UTR

chr8:143430581-C-T

0.003

0.223

−0.813

−0.354

ERMAP

nonsynonymous

ERMAP:exon11|chr1:42842592-G-A|

0.003

0.139

−0.108

0.151

KIR2DL1, KIR2DL2, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS5, LOC102725023, LOC112267881

intronic

chr19:54782910-A-C;chr19:54783557-G-A

0.002

0.462

−0.285

0.541

KCNK2

5′ UTR

chr1:215083228-T-C

0.002

0.640

−0.571

NA

TNN

synonymous

TNN:exon9|chr1:175098411-C-T|

0.002

0.300

−0.306

0.691

PTPRF

nonsynonymous

PTPRF:exon27|chr1:43620173-C-A|

0.002

0.165

−0.177

1.194

HAPLN1

intronic

chr5:83675345-GGA,G-G,A

0.002

0.230

−0.291

NA

TXNDC11

intronic

chr16:11690739-T-C

0.002

0.115

−0.464

0.048

ADGRV1

nonsynonymous

ADGRV1:exon52|chr5:90745757-T-C|

0.002

0.122

−0.123

−0.437

ST3GAL5

5′ UTR

chr2:85853868-G-A

0.002

0.387

−0.221

0.087

LRRN4CL

synonymous

LRRN4CL:exon2|chr11:62687993-G-A|

0.002

0.103

−0.261

−0.102

PBXIP1

nonsynonymous

PBXIP1:exon7|chr1:154946733-C-T|

0.002

0.110

−0.349

−0.183

C16orf86

intronic

chr16:67667541-G-C

0.002

0.581

−0.559

−0.772

MTFR2

synonymous

MTFR2:exon7|chr6:136233490-G-A|

0.002

0.156

−0.393

−0.168

PRSS48

synonymous

PRSS48:exon3|chr4:151282385-C-T|

0.001

0.116

−0.192

NA

GLIPR2

5′ UTR

chr9:36136627-G-A

0.001

0.150

−0.310

0.218

GPC5

5′ UTR

chr13:91398687-A-G,*;chr13:91398864-C-G;chr13:91398884-T-G

0.001

0.191

−0.347

−0.433

METTL6

5′ UTR

chr3:15427483-G-C,A

0.001

0.126

−0.324

−0.174

VWA5B1

nonsynonymous

VWA5B1:exon5|chr1:20317549-G-A|

0.001

0.409

−0.245

0.444

NIN

intronic

chr14:50737492-T-A

0.001

0.500

−1.500

−0.057

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