Table 1 Description of sample.

From: Effects of antipsychotics on human cognitive function: causal evidence from healthy volunteers following sustained D2/D3 antagonism, D2/D3 partial agonism and placebo

 

Amisulpride (n = 25)

Aripiprazole (n = 25)

comparison

Sex

Female 15 (60%); Male 10 (40%)

Female 14 (56%); Male 11 (44%)

p = 0.78

Age (Years)

26.5 (7.6)

26.7 (8.7)

Mann-Whitney U: p = 0.82

Ethnicity

White 15, Asian 4, Black 1, Mixed/Other 5

White 16, Asian 5, Black 2, Mixed/Other 2

p = 0.62

BMI

23.6 (3.8)

22.4 (3.5)

2 sample t-test p = 0.25

Education

Postgraduate 6, Undergraduate 13, High School 4, Professional Qualification 1

Postgraduate 9, Undergraduate 6, High School 9, Other 1

p = 0.15

Employment

Student 19, Employed 6

Student 16, Employed 9

p = 0.36

Treatment order

Amisulpride first 13 (52%), placebo first 12 (48%)

Aripiprazole first 12 (48%), placebo first 13 (52%)

p = 0.78

Plasma levels (ug/L)

312.4 (SD 203.0). Range 29–719)

Aripiprazole 95.8 (SD 33.3). Range 35–174

Aripiprazole + De-hydroaripiprazole 126 (31.4). Range 58–193

N/A

Washout length (days)

23.6(13.7). Range 12–64

52.6 (37.6). Range 28–168

N/A

Time from last dose to cognitive testing (hours)

13.6 (4.1). Range 4.8–21.1

27.5 (3.5). Range 17.7–33.6

N/A

  1. Values are mean (SD) for continuous variables, and frequencies for categorical variables unless otherwise stated.
  2. Comparisons between demographic variables were performed using two-sided independent sample t-tests or Mann-Whitney U tests for continuous variables, and chi-squared tests for categorical variables.
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