Table 2 Effects of amisulpride vs placebo and aripiprazole vs placebo on SART outcomes.

From: Effects of antipsychotics on human cognitive function: causal evidence from healthy volunteers following sustained D2/D3 antagonism, D2/D3 partial agonism and placebo

Amisulpride

 

Outcome variable

Amisulpride estimated marginal mean (SEM)

Placebo estimated marginal mean (SEM)

Fixed effect of amisulpride (beta)

SE of beta value

p-value (amisulpride vs placebo)

Model R2

p-value (effect of order)

Balanced Integration Score

1.0 (0.3)

1.1(0.4)

−0.16

0.26

0.55

0.69

0.37

Reaction time

315.9 (10.1)

313.4 (8.5)

2.51

6.84

0.72

0.90

0.76

Errors commission

6.0 (1.1)

6.3 (1.2)

−0.043

0.12

0.72

0.56

0.79

Errors omission

1.1 (1.35)

0.6 (1.4)

0.54

0.34

0.12

0.52

0.40

Total errors

6.9 (1.1)

7.0 (1.2)

−0.0073

0.11

0.94

0.67

0.89

Aripiprazole

 

Outcome variable

Aripiprazole estimated marginal mean (SEM)

Placebo estimated marginal mean (SEM)

Fixed effect of aripiprazole (beta)

SE of beta value

p-value (aripiprazole vs placebo)

Model R2

p-value (effect of order)

Balanced Integration Score

1.5 (0.3)

1.2 (0.4)

0.22

0.31

0.49

0.88

0.16

Reaction time

325.4 (13.6)

320.3 (8.5)

5.12

10.0

0.61

0.88

0.72

Errors commission

4.5 (1.2)

4.5 (1.2)

0.02

0.15

0.90

0.65

0.69

Errors omission

0.4 (1.5)

0.5 (1.6)

0.16

0.33

0.64

0.64

0.07

Total errors

5.1 (1.2)

5.2 (1.2)

−0.019

0.15

0.90

0.83

0.26