Table 3 Association of the PGS (as a continuous variable) with depression trajectory classes.

From: Genomic risk prediction for depression in a large prospective study of older adults of European descent

Depression trajectory class comparison

Model 3.2

OR (95% CI)

P

Non-depressed (reference level) vs. Subthreshold depression

1.15 (1.11–1.20)

3.37E-12

Emerging depression

1.22 (1.13–1.31)

5.01E-07

Persistent depression

1.40 (1.31–1.49)

1.62E-22

Subthreshold depression (reference level) vs. Emerging depression

1.06 (0.98–1.14)

0.17

Persistent depression

1.21 (1.13–1.30)

2.45E-08

Emerging depression (reference level) vs. Persistent depression

1.15 (1.05–1.26)

3.91E-03

  1. Non-depressed, n = 5536; Subthreshold depression, n = 4625; Emerging depression, n = 779; Persistent depression, n = 1089. Multinomial logistic Model 3.2 was used to estimate the odds ratio (OR) of the polygenic score (PGS) per standard deviation, with 95% confidence intervals (CI). The model was adjusted for age, sex, the first 20 principal components of genetic ancestry, living status, education attainment, smoking status, alcohol drinking status, and body mass index.
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