Fig. 1: Associations of baseline and longitudinal changes in plasma AD-related biomarkers with cognitive decline over time by using linear mixed-effects models. | Molecular Psychiatry

Fig. 1: Associations of baseline and longitudinal changes in plasma AD-related biomarkers with cognitive decline over time by using linear mixed-effects models.

From: Associations between trajectories of plasma biomarkers for Alzheimer’s disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank

Fig. 1

Beta-coefficients (95% confidence intervals) were derived from the linear mixed effects-models that were adjusted for sex, age, ethnicity, townsend deprivation index, assessment center, smoking status, alcohol use, APOE ε4 allele, hypertension, diabetes, cardiovascular arterial disease, and history of COVID-19 infection. Significance levels were corrected for multiple comparisons using the Benjamini-Hochberg FDR method: *FDR-corrected P < 0.05. Aβ amyloid-β, GFAP glial fibrillary acidic protein, NfL neurofilament light chain, p-tau181 phosphorylated tau 181, CI confidence interval.

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