Fig. 4: Associations of baseline and longitudinal changes in plasma AD-related biomarkers with longitudinal changes in white matter microstructure. | Molecular Psychiatry

Fig. 4: Associations of baseline and longitudinal changes in plasma AD-related biomarkers with longitudinal changes in white matter microstructure.

From: Associations between trajectories of plasma biomarkers for Alzheimer’s disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank

Fig. 4

Panel A demonstrates the association between baseline plasma levels and changes in white matter microstructure, while panel B illustrates the association between changes in plasma levels over time and corresponding changes in white matter microstructure (*FDR-corrected P < 0.05). Beta-coefficients (95% confidence intervals) were derived from the linear mixed effects-models that were adjusted for sex, age, ethnicity, townsend deprivation index, assessment center, smoking status, alcohol use, APOE ε4 allele, hypertension, diabetes, cardiovascular arterial disease, history of COVID-19 infection, and total intracranial volume. GFAP glial fibrillary acidic protein, NfL neurofilament light chain, FA fractional anisotropy, MD mean diffusivity, ICVF intracellular volume fraction, ISOVF isotropic volume fraction, OD orientation dispersion, r right, l left.

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