Fig. 4: Impairment of OXPHOS protein complex in BD iAstrocytes. | Molecular Psychiatry

Fig. 4: Impairment of OXPHOS protein complex in BD iAstrocytes.

From: Differential effects of lithium on metabolic dysfunctions in astrocytes derived from bipolar disorder patients

Fig. 4: Impairment of OXPHOS protein complex in BD iAstrocytes.

a Diagram depicting the analysis of mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) level of iAstrocytes using JC-1 and DCFDA, respectively. b Relative MMP ratios of iAstrocytes (n = 3). c Relative ROS level ratios of iAstrocytes (n = 3). d Western blots showing mitochondrial respiratory chain complex I-V subunits of iAstrocytes. C refers to Ctrl, R refers to Li-R, and NR refers to Li-NR. e, f Quantification of band intensity of Western blot result. COX2 and SDHB expression levels were normalized to the control protein, a-TUBULIN (n = 3).

Back to article page