Fig. 2: The interrelations between dopamine synthesis in striatum, GABA levels in anterior cingulate cortex, and glutamate levels in left thalamus. | Molecular Psychiatry

Fig. 2: The interrelations between dopamine synthesis in striatum, GABA levels in anterior cingulate cortex, and glutamate levels in left thalamus.

From: Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response

Fig. 2

A An inverse relationship was observed between decarboxylation rate (k3) in nucleus accumbens (NAcc) and GABA levels in anterior cingulate cortex (ACC) in antipsychotic-naïve patients with first-episode psychosis (AN-FEP) (red circles) compared to healthy controls (HC) (blue triangles) (p = 0.002, Table 2, Model 1) due to a positive association in AN-FEP (p = 0.04, β = 0.15) but a negative in HC (p = 0.03, β = −0.15). B A positive association was found between k3 in NAcc and glutamate levels in thalamus in both AN-FEP and HC (p = 0.04, b = 0.04). DS dopamine synthesis, NAcc nucleus accumbens, ACC anterior cingulate cortex, AN-FEP antipsychotic-naïve patients with first-episode psychosis, HC healthy controls, IU Institutional units.

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