Fig. 3: Relations between treatment response, striatal DS, and metabolite levels.
The effect of k3 (NAcc) and either GABA levels in ACC (A) or Glu levels in thalamus (B) and their interaction on the treatment response (change in PANSS positive). The colorbars indicate the change in PANSS positive score after treatment, where a positive change indicates worsening symptoms, and a negative change indicates improvement. The white dots illustrate the individual patients. The neurotransmitters are standardized to zero mean and unit variance. A) Illustrates the significant interaction between k3 and GABA in ACC. If both k3 and GABA are either low or high, the patient improves during the six weeks of treatment (dark blue). In contrast, if GABA is high and k3 is low or opposite, the patient has more symptoms after treatment (yellow). B) Illustrates a significant effect of k3 on the treatment response, but no interaction effect between k3 and Glu in thalamus: the treatment response only depends on the value of k3, i.e., the color only changes along the x-axis and not along the y-axis.
