Fig. 1: Spatial enrichment of group-level cortical thickness (CT) alterations in anorexia nervosa (AN), depicting CT alterations in AN and relevant intersection with chemoarchitecture density maps. | Molecular Psychiatry

Fig. 1: Spatial enrichment of group-level cortical thickness (CT) alterations in anorexia nervosa (AN), depicting CT alterations in AN and relevant intersection with chemoarchitecture density maps.

From: Mapping the path to recovery: the intersection of cortical thickness reductions and serotonin transporter expression in anorexia nervosa

Fig. 1

Left column (A): Whole-brain CT alterations in individuals with AN compared to healthy controls. Color scale: contrast map (in cm) of the group comparison—blue indicates lower CT in AN, and red indicates higher CT in AN; Right column (B, C, D, E): Regions with marked CT differences were defined as those showing a group difference of ±0.1 cm. Chemoarchitectural feature maps were thresholded at 1 standard deviation (SD) from the mean (except for Glc, which was thresholded at 0.5 SD to enhance visual clarity). Intersected regions were further thresholded to a minimum cluster size of 15 vertices. The most prominent resulting intersections are displayed to facilitate visual comparison. Overlays of CT and chemoarchitecture maps can be found in Supplementary Fig. S2. B AChN, Acetylcholine nicotinic receptor; C: HT1a, serotonin receptor; D SERT, Serotonin transporter; E: Glc, glucose metabolism.

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