Table 2 Genome- and epigenome-wide associations of SNP by cumulative prenatal stress interactions and DNA methylation.

From: Interactive effects of genotype with prenatal stress on DNA methylation at birth

SNP

SNP CHR:BP

CpG

CpG CHR:BP

B (SE)

p

adjusted R2*

direction†

I2

(nearest) gene SNP‡

(nearest) gene CpG‡

SNP-CpG distance (bp)

rs12901653

15:93488404

cg24317086

15:93423542

-0.0262 (0.0032)

4.067Ă—10-16

0.03

--+

93.5

CHD2

(CHASERR)

64,862

rs76542426

7:103856777

cg06592260

8:144941878

-0.0128 (0.0017)

1.12Ă—10-13

0.02

---

0.0

(ORC5)

EPPK1

41,085,101

rs10279675

7:103846781

cg06592260

8:144941878

-0.0123 (0.0017)

2.76Ă—10-13

0.02

---

0.0

ORC5

EPPK1

41,095,097

rs2188287

7:103867883

cg06592260

8:144941878

-0.0126 (0.0017)

1.85Ă—10-13

0.02

---

0.0

(ORC5)

EPPK1

41,073,995

rs10251976

7:103834690

cg06592260

8:144941878

-0.0124 (0.0017)

7.32Ă—10-13

0.02

---

0.0

ORC5

EPPK1

41,107,188

  1. * Adjusted R [2] represents a sample-size weighted average over the (sub-)cohorts.
  2. † Direction indicates direction of estimate for GENR 450 K, GENR EPIC, and ALSPAC 450 K, respectively.
  3. ‡ For intergenic SNPs and CpGs the nearest gene is indicated in brackets.